SOLUBLE FORMS OF PD-L1 AND PD-1 AS PROGNOSTIC AND PREDICTIVE MARKERS OF SUNITINIB EFFICACY IN PATIENTS WITH METASTATIC CLEAR CELL RENAL CELL CARCINOMA

Metastatic clear cell renal cell carcinoma (mccRCC) benefits from several treatment options in the first-line setting with VEGFR inhibitors and/or immunotherapy including anti-PD-L1 or anti-PD1 agents.Identification of predictive biomarkers is highly needed to optimize patient care.Circulating markers could reflect the biology of metastatic disease

This paper investigates the dynamic response of the compliant tilting Steamer pad journal bearings subjected to synchronous excitation.Bearing compliance is affected by the properties of pad liner and pad support geometry.Different unbalance eccentricities are considered.It is shown that bearing dynamic response is non-linear.Journal orbit complexi

Tilting of buildings due to uneven settlement, construction quality issues or other problems is one of the critical accidents threatening the safety of buildings.In order to determine a reasonable solution with respect to the rectification of the tilting building, detection of the stresses of the substructure is necessary.In this study, a stress re

ABSTRACT: Several cage-free egg mandates and retailer pledge deadlines are set to take effect in January 2026.Yet it is unknown whether producers can transition to cage-free production at Brush Set a rate commensurate with these goals.This study uses qualitative and quantitative data from 2 U.S.egg producer surveys to evaluate the operational activ